The addition of antimicrobial drugs to the emulsion has been instituted in some countries, but outbreaks have still occurred. Related factors included reuse of syringes for multiple patients and prolonged exposure to the environment when vials were left open. Twenty propofol-related outbreaks have been reported, affecting 144 patients and resulting in 10 deaths. In this overview of the evidence of propofol as a source of infection and appraisal of preventive strategies, we identified 58 studies through a literature search in PubMed, Embase, and Lilacs for propofol-related infections during 1989–2014. Little is known regarding the global epidemiology of propofol-related outbreaks and the effectiveness of existing preventive strategies. Mirski, MD, PhD, have disclosed no relevant financial relationships.Īdministration of propofol, the most frequently used intravenous anesthetic worldwide, has been associated with several iatrogenic infections despite its relative safety. Arevalo, MD, MSc Kevin Escandón-Vargas, MD Daniel Soltanifar, MBBS, FRCA and Marek A. McNeil Consumer Healthcare served as a speaker or a member of a speakers bureau for Shire Pharmaceuticals.ĭisclosurea: Andrés Zorrilla-Vaca Jimmy J.
Vega, MD, has disclosed the following financial relationships: served as an advisor or consultant for Allergan, Inc. Vega, MD, Clinical Professor of Family Medicine, University of California, Irvine. Disclosure: Jean Michaels Jones has disclosed no relevant financial relationships.Ĭharles P.
Jean Michaels Jones, Technical Writer/Editor, Emerging Infectious Diseases.
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